Details

The Interferons

Characterization and Application
1. Aufl.

von: Anthony Meager
151,99 €
Verlag:	Wiley-Blackwell (WB)
Format:	PDF
Veröffentl.:	21.08.2006
ISBN/EAN:	9783527607921
Sprache:	englisch
Anzahl Seiten:	460

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Beschreibungen

Titelbeschreibung

At long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist, chapters include discussions of interferon genes, Type I, II and III IFNs, as well as their induction, production and purification, receptors actions, measuring IFN activities and anti-IFN antibodies, as well as the evolution of viral defense mechanisms. For immunologists, cancer researchers, medicinal chemists, cell biologists, developmental biologists and the pharmaceutical industry.

Inhaltsverzeichnis

I MOLECULAR ASPECTS, INTRODUCTION AN PURIFICATION Samarajiwa (and colleagues): Genetics and characterization of the type I IFN locus Hiscott: Induction of IFNs by IRFs Foster: Interferon proteins: structure, production and purification Young (and colleagues): IFN gamma: gene and protein structure, transcription regulation and actions Pestka: Interferon and related receptors Kotenko: Type III Interferons: The Interferon lambda family II BIOLOGICAL PROPERTIES Fish (and colleagues): Biological actions of type I IFNs Clemens: Interferons and apoptosis Hertzog (and colleagues): IFNs and Toll-like receptor (TLR) signalling Banerjee and Bose: Viral defence mechanisms against interferon III CLINICAL APPLICATIONS Müller: Overview of clinical applications of type I Interferons Czarniecki: Clinical applications of IFN-gamma IV MEASUREMENT OF INTERFERONS AND ANTI-INTERFERONS Meager: Measurement of interferon activities Grossberg and Kawade: Measurement of antibodies to interferon

Rezension

"The book is an up-to-date reference critical to researchers focused on one or another aspect of interferon biology. It also offers a comprehensive introduction with a good bit of historical perspective to researchers, including graduate students, who are new to the field. Many chapters will also appeal to those investigators whose research only partly overlaps with the interferons." ChemMedChem

Autorenportrait

Anthony Meager is a Principal Scientist in the Division of Immunology and Endocrinology, The National Institute for Biological Standards and Control (NIBSC), UK. Following his PhD in Biochemistry (Warwick University, UK, 1972), he has carried out research in biochemistry, cell biology, immunology, virology, and cytokines, especially interferons (IFN) and tumor necrosis factor (TNF). He joined the NIBSC in 1980. Currently, he heads laboratories involved in the biological standardization of IFN and TNF, and research studies on the bioactivity and immunogenicity of cytokines. From 1990, he has also contributed to regulatory guidance on gene therapy, both for the European Medicines Agency and the World Health Organization.

Back cover copy

At long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist, chapters include discussions of interferon genes, Type I, II and III IFNs, as well as their induction, production and purification, receptors actions, measuring IFN activities and anti-IFN antibodies, as well as the evolution of viral defense mechanisms. For immunologists, cancer researchers, medicinal chemists, cell biologists, developmental biologists and the pharmaceutical industry.