Details

Novel Vaccination Strategies

1. Aufl.

von: Stefan H. E. Kaufmann
151,99 €
Verlag:	Wiley-Blackwell (WB)
Format:	PDF
Veröffentl.:	24.01.2006
ISBN/EAN:	9783527606092
Sprache:	englisch
Anzahl Seiten:	670

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Beschreibungen

Titelbeschreibung

The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.

Inhaltsverzeichnis

PART I Preface Introduction: Challenges for the vaccine developer, including correlates of protection PART II VACCINATION AND IMMUNE RESPONSE Shaping adaptive immunity against pathogens: the contribution of innate immune responses Adjuvant induced Th2 and Th1 dominated immune responses in vaccination Memory T-cell based vaccines PART III ADJUVANTS Microbial adjuvants Host derived adjuvants Microparticles as vaccine adjuvants and delivery systems Liposomes and ISCOMs Virosomal technology and mucosal adjuvants PART IV CLASSICAL AND NOVEL VACCINATION STRATEGIES: A COMPARISON Classical bacterial vaccines Subunit vaccines and toxoids Engineering virus vectors for subunit vaccines Update on antiviral DNA vaccine research (2000-2003) Live recombinant bacterial vaccines Mucosal vaccination Passive vaccination and antidotes: A novel strategy for generation of wide-spectrum protective antibodies Plant-based oral vaccines Virus-like particles: Combining innate and adaptive immunity for effective vaccination PART V VACCINES FOR SPECIFIC TARGETS Helicobacter pylori Tuberculosis: Novel vaccination strategies against tuberculosis Rationale for malaria vaccine development HIV Vaccines against bioterror agents Part VI VACCINES IN THE REAL WORLD: SAFETY, COST-EFFICIENCY AND IMPACT OF VACCINATION Imperfect vaccines and the evolution of pathogen virulence Cost-effectiveness of vaccinations Immunological safety of vaccines: facts, hypothesis and allegations Index

Rezension

"...enjoyed reading the book immensely, found it very informative and a good mixture of basic and applied science...definitely recommended..." Immunology News, August 2004 "This would be a valuable text for those in the field with the expertise." E-STREAMS, October 2004 "This book thoroughly reviews our understanding of the immunologic response to infectious diseases and the many advances in the development of vaccines...Stefan Kaufmann, who is the founding director of the Max Planck Institute for Infection Biology in Berlin, has brought together a group of experts in various fields of vaccinology from Europe, the United States, and Australia for this challenging project. Immunologists, developers of vaccines, clinical-trial specialists, and molecular biologists will find this book to be of interest...An outstanding section of the book is dedicated to adjuvants and vaccine vectors...I recommend this book to microbiologists, epidemiologists, and practitioners who administer vaccines. Indeed, reading the chapter...is fascinating for all specialists." New England Journal of Medicine, November 4, 2004 "The presentations are concise, clear, well illustrated, and provide an excellent survey of the subject overall." IEEE Engineering in Medicine and Biology, Jan/Feb 2005 "Dr. Kaufmann and eminent contributors, with their outstanding expertise, created an excellent resource for medical professionals and biomedical scientists." Annals of Biomedical Engineering, December 2004

Autorenportrait

Prof. Dr. Stefan H.E. Kaufmann, Scientific member of the Max Planck Society, Founding Director of the Max Planck Institute for Infection Biology, Berlin. More than 500 publications and reviews on immunology and infection. Member of numerous scientific societies and committees and winner of prestigious awards. One of the 100 most cited immunologists in the period of 1981 to 1999.

Back cover copy

The protection mode of the majority of vaccines is based on the induction of antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that can activate the full array of the immune response and should prevent pathogen entry by mobilizing the local mucosal immune response. New technological advances make it possible to optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.