Details

Biomedical Applications of Proteomics

1. Aufl.

von: Jean-Charles Sanchez, Garry L. Corthals, Denis F. Hochstrasser
201,99 €
Verlag:	Wiley-Blackwell (WB)
Format:	PDF
Veröffentl.:	06.03.2006
ISBN/EAN:	9783527605835
Sprache:	englisch
Anzahl Seiten:	452

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Beschreibungen

Titelbeschreibung

In this first book to provide an overview of applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets, a team of international specialists from research institutions, hospitals and companies contribute with their specific expertise. They cover a wide range of example applications for the most important diseases, such as heart and cardiovascular disorders, cancer, pharmatoxicology, infectious diseases and diseases of the nervous system. Denis Hochstrasser is an eminent scientist in the field of bioinformatics and proteomics and one of the founders of the Swiss Prot Databank as well as of the Swiss biotech company Genebio.

Inhaltsverzeichnis

Preface SECTION I: ASPECTS OF BIOMEDICAL RESEARCH Proteomics in Biomedicine - A Tool, a Science or an Art? SECTION II: BLOOD VESSELS Antibody-Based Vascular Targeting: Proteomic Techniques for the Identification and Quantitation of Membrane Proteins on Endothelial Cells Vasculature, Vascular Disease and Atherosclerosis Discovery of New Diagnostic Markers of Stroke SECTION III: CANCER Unravelling Biological Pathways and the Identification of Clinical Markers and Targets in Renal Cancer HSP27 in Cancer Proteomic Approaches for Biomarker Discovery in Colorectal Cancer Clinical Proteomics: Ovarian Cancer Protein Expression Profiling Analysis in Hematopoietic Stem Cells: Phenotypic Characterization of Mesenchymal Stem Cells Lymphoblastoid and Lymphoma Cells SECTION IV: PHARMACO-TOXICOLOGY Chemoresistance in Cancer Cells Diabetes Mellitus: Complex Molecular Alterations) SECTION V: INFECTIOUS DISEASES Proteome Approach to Infectious Diseases New Insights Into HIV Lymphocyte Infection Modifications of Host-Cell Proteomes Induced by Herpes Virus Type 1 Francisella Tularensis SECTION VI: CENTRAL NERVOUS SYSTEM Proteomics in Clinical Neurosciences Human Cerebrospinal Fluid Proteomic Applications for Molecular Assessment of Alzheimer's Disease SECTION VII: MASS SPECTROMETRY AND BIOINFORMATICS MALDI MS Imaging in Biomedical Research Protein Variations: Resources and Tools

Rezension

"In spite of the complexity of many diseases as well as proteomic approaches that may be applied, the style of the book is generally clear and straightforward in its presentation." Proteomics "This book is a good reference resource for all academic and other researchers who are interested in how proteomics is applied in biomedicine." E-STREAMS "... a nice overview of biomedical proteomics applications." Clinical Chemistry "...those new to the field can use the book to quickly catch up on applications of proteomics. ... the book [is also] a great resource for literature and techniques." Environmental Health Perspectives "...this book is a compendium of biomedical publications covering a wide range of state-of-the-art proteomic techniques and aimed to give a detailed view what current proteomic technologies can serve for in biomedical research. The clear style of the book and its straightforward presentations provides profound insight to scientists. Furthermore, it serves as a good resource for literature and techniques for academic and other researchers interested in the implementation of proteomics in biomedicine. (...) Overall the editors provide a comprehensive overview on biomedical proteomics applications for both, protein analysts familiar with state-of-the-art proteome technologies as well as physicians in molecular medicine." Arneimittel-Forschung/Drug Research

Autorenportrait

Jean-Charles Sanchez has been working since 1989 in the field of proteomics. He contributed in the development of two-dimensional polyacrylamide gel electrophoresis and related procedures and their application in Biomaker discovery research. He obtained his Ph.D. in Biochemistry at the Buckingham University (UK) and in 1997 a Business Administration diploma (Officer School of Lausanne). Since 1995, he has been the head of the Biomedical Proteoomics Group at the BPRG at the Geneva University Hospital. He is a founder of the Swiss Proteomics Society, Swiss-2Dservice and Phenomics Sciences Consulting. The activities in his group cover the discovery of new disease markers and drug targets in multi-factorial disorders including cancer, Alzheimer, CJD, stoke, obesity and type II diabetes. Garary L. Corthals has been involved in proteomics for over 10 years and has focused on integrating MS technologies for protein analysis in biomedical research. His current interests include development of technologies for rapid and sensitive protein analysis to discover new diagnostic markers for disease and to elucidate cellular processes that direct physiological behaviour. Other activities include the synthesis of new chemistries for accurate quantitation or proteins and the concurrent analysis of PTMs; as well as technologies for capturing high density protein profiles. He obtained his Ph.D. in Biology at Macquarie University (Australia) in the field of proteomics. Before arriving in Geneva he worked in the Department of Molecular Biotechnology (UW, Seattle) and directed the Proteomics Facility at the Garvan Institute of Medical Research in Sydney (Australia). He currently heads the MS Group at the BPRG at Geneva University Hospital and is co-director of the Proteomics Facility of the Faculty of Medicine. Denis F. Hochstrasser is the director of the Clinical Pathology Department and Head of the Clinical Chemistry Laboratory of the Geneva University Hospital. He obtained his M.D. at Geneva Medical School, and did his internship and residency at UNC, Chapel Hill (USA). He is known for his pioneering development of what is now called proteomics. He initiated work on software development for proteomics data processing 15 years ago and has contributed to the development of the leading 2-D gel analysis software Melaine and related 2-D-PAGE database. He was instru-mental the creation of ExPASy, the fist life sciences devoted web server. Most recently he has been responsible for the Molecular Scanner, a technique that promises to enhance clinical proteomic analysis. He is a founder of the Swiss Institute for Bioinformatics and scientific founder of GeneProt & GeneBio.

Back cover copy

The first book to provide an overview over applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets. Examples of applications are presented for the most important diseases like heart and cardiovascular disorders, cancer, infectious diseases and diseases of the nervous system. Aspects of pharmatoxicology as well as bioinformatics are also included. Authors form the U.S., Europe and Australia contribute with their specific expertise. They are professionals from research institutions, hospitals and companies.